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KMID : 0361620050400070977
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Journal of the Korean Orthopaedic Association
2005 Volume.40 No. 7 p.977 ~ p.983
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Nerve Regeneration after Modified End-to-Side Neurorrhaphy in the Rat
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Kim Byung-Sung
Choy Won-Sik
Baek Goo-Hyun
Chung Moon-Sang
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Abstract
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Purpose: The aim of this study was to evaluate the effect of modified end-to-side neurorrhaphy on functional recovery, by modulating the epineurial window and contact areas with a donor nerve, using a rat median nerve and finger flexors.
Materials and Methods: Four experimental groups (n=10) were used: a large epineurial window and a spiral circumferential contact with the donor nerve (Group A): a large epineurial window and half a contact with the donor nerve (Group B): a small epineurial window and half a contact with the donor nerve
(Group C): and a nontransferred control (Group D). Grasping testing, muscle contractility testing, and a histological study were performed.
Results: Twenty weeks after surgery, the grasping strength, tetanic force and nerve fiber count were significantly higher in group A than group C. The modified end-to-side repair can enhance axonal sprouting from an intact nerve, and improve functional recovery.
Conclusion: Either the epineurial window surface area or the contact configuration with the donor nerve is an important factor in an end-to-side coaptation model.
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KEYWORD
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Peripheral nerve injury, Epineurial window area, Contact area with donor nerve, Nerve regeneration
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